小鼠Wnt-3a蛋白抑制剂(WNT3A)信号通路(5ug,W3A-M-005,r&d )简述:
WNT-3a是WNT信号蛋白家族的一员,扮演一个在胚胎发育和成年组织的完整性关键的角色。WNT-3a是对于规范通过beta-catenin WNT信号通路。小鼠WNT-3a的预测大小是一个含有333个氨基酸残基的单体的蛋白质。由于糖基化,它的表观分子量40间迁徙kDa缩条件下分别分析。StemRD的产品从小鼠细胞序列段表示。
干细胞生长分化因子与人间充质干细胞是属于研究干细胞科学zui常用的试剂与培养基,目前各大研发机构都从本公司购买,两者一起购买优惠哦!
小鼠Wnt-3a蛋白抑制剂(WNT3A)信号通路(5ug,W3A-M-005,r&d )英文简述:
WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. WNT-3a is a prototypic canonical WNT that signals through the beta-catenin pathway. The predicted size of mouse WNT-3a is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under non-reducing conditions. StemRD’s product is expressed from a mouse cell line over-expressing mouse WNT-3a. We express and purify WNT proteins by using a proprietary process that is distinctive from the published protocol. Our method results in WNT proteins that are purer and more active than market-leading products which have been associated with non-specific artifacts.
小鼠Wnt-3a作为上海代理temRD公司的系列产品之一,其他相关系列产品还有:
小鼠Wnt-3a
小鼠Wnt-3a蛋白抑制剂(WNT3A)信号通路(25ug,W3A-M-025,r&d )
小鼠Wnt-3a蛋白抑制剂(WNT3A)信号通路(100ug,W3A-M-100,r&d )
产品英文名称:StemRD W3A-M-100 WNT-3a,Mouse,100ug
产品中文名称:StemRD W3A-M-100 小鼠WNT-3a 蛋白因子,100ug
StemRD W3A-M-100 WNT-3a,Mouse,100ug 产品简介
wnt通路是细胞增殖分化的关键调控环节, 在胚胎发育和肿瘤发生中起着重要作用。wnt途径参与了基因表达调节、 细胞迁移粘附、细胞极化等过程,同时还与其它信号通路存在交叉协同。Wnt/β-catenin通路在进化过程中高度保守,此通路的主要分子构成及相关调 控机制已得到基本阐明。对神经系统而言已有足够证据显示此通路参与了对神经前体细胞增殖, 分化以及决定细胞命运的调控。
Wnt-3a 干细胞生长分化因子是Wnt基因家族中重要成员,zui近的一些研究发现, Wnt-3a 干细胞生长分化因子信号蛋白对神经干细胞的定向分化的调控作用表现的十分明显。小鼠WNT-3a 干细胞生长分化因子蛋白包含328个氨基酸。
Wnt蛋白是存在于多种生物体内的一种细胞外配体,Wnt作为形态发生素通过激发细胞内远离信号发送区域的浓度依赖反应控制胚胎形态发育。Wnt通路调节动物 发育过程中的多个重要环节,例如细胞增殖、细胞迁徙及细胞分化。Wnt蛋白通过自分泌或旁分泌作用与位于细胞膜上的受体相结合,激活细胞内信号通路调节靶 基因的表达,对细胞的增殖、分化、迁移、极性化和凋亡起到重要作用。
WNT 信号转导通路因其启动蛋白为Wnt蛋白而得名,在胚胎发育、细胞增殖及分化等方面发挥重要 作用,其异常活化与人类多种肿瘤的发生密切相关。研究显示,Wnt信号至少存在经典和非经典两条不同的信号通路,而Wnt-5a属于非经典Wnt信号通 路,既往研究Ror2具有Wnt受体结构域样结构。有研究认为Wnt-5a经由Ror2介导的 信号通路发挥作用。
Human WNT-5a蛋白含有357个氨基酸残基。
StemRD W3A-M-100 小鼠WNT-3a 蛋白因子,100ug 产品特性
» StemRD W3A-M-100 小鼠WNT-3a 蛋白因子,100ug 干细胞生长分化因子活性经过NIH 3T3 细胞鉴定,纯度高
» StemRD W3A-M-100 小鼠WNT-3a 蛋白因子,100ug干细胞生长分化因子生物活性在NIH 3T3 细胞经过TCF报告基因实验鉴定The EC50为 50–150 ng/ml
» StemRD W3A-M-100 小鼠WNT-3a 蛋白因子,100ug 干细胞生长分化因子产品经过SDS-PAGE 和HPLC双层鉴定纯度大于90%
StemRD W3A-M-100 WNT-3a,Mouse,100ug 保存方法
The lyophilized protein is stable for at least 6 months if stored at -80 degreeC. Reconstituted protein is stable for at least two weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.
StemRD W3A-M-100 WNT-3a,Mouse,100ug 产品英文描述
WNT-3a is a member of the WNT family of signaling proteins that play a key role in embryonic development and the integrity of adult tissues. StemRD W3A-M-100 WNT-3a,Mouse,100ug is a prototypic canonical WNT that signals through the β-catenin pathway. The predicted size of mouse StemRD W3A-M-100 WNT-3a,Mouse,100ug is a monomeric protein containing 333 amino acid residues. Due to glycosylation, it migrates at an apparent molecular weight of 40 kDa by SDS-PAGE analysis under nonreducing conditions. StemRD’s product W3A-M-100 WNT-3a,Mouse,100ug is expressed from a mouse cell line overexpressing mouse WNT-3a. Purification is performed with a proprietary process that is distinct from the published method.
? StemRD W3A-M-100 WNT-3a,Mouse,100ug Purity: Greater than 90% as determined by SDS-PAGE analysis
? StemRD W3A-M-100 WNT-3a,Mouse,100ug Biological Activity: The activity was determined by using a TCF reporter gene assay in NIH3T3 cells. The EC50 ranges from 50 – 150 ng/ml. Country of Origin USA
StemRD W3A-M-100 小鼠WNT-3a 蛋白干细胞生长分化因子系列产品订购信息
StemRD W3A-M-005 WNT-3a,Mouse 5ug 优惠价格请
StemRD W3A-M-025 WNT-3a,Mouse 25ug 优惠价格请
StemRD W3A-M-100 WNT-3a,Mouse 100ug 优惠价格请
StemRD W5A-M-005 WNT-5a,Mouse 5ug 优惠价格请
StemRD W5A-M-025 WNT-5a,Mouse 25ug 优惠价格请
StemRD W3A-M-100 WNT-5a,Mouse 100ug 优惠价格请