多球壳菌素


基本信息

产品名称 多球壳菌素
英文名称 Myriocin
别名 Myriocin;ISP-1
英文别名 (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin
应用 An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
规格或纯度 98%
运输条件 超低温冰袋运输
生化机理 Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been sμggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.Highly potent serine palmitoyltransferase inhibitor (K i = 0.28 nM). Shows 10 times the immunosuppressant potency of cyclosporine . Depletes cellular sphingolipids and induces apoptosis. Inhibits proliferation (IC 50 = 15 nM, CTLL-1

一般描述

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.

Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.
An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.

安全信息

标识符号 多球壳菌素 GHS06
信号词 Danger
警示性声明 P301+P310
危害声明 H301
个人防护设备 dust mask type N95 (US),Eyeshields,Faceshields,Gloves
WGK 3
UN Number 2811

相关属性

CAS编号 35891-70-4
敏感性 对光线和湿度敏感
溶解性 Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water.
储存温度 -20°C储存
RTECS JX3890000
MDL号 MFCD01632772
密度 1.123
分子量 401.54
分子式 C21H39NO6
品牌 金畔生物
备注 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
PubChem CID 6438394

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