Dojindo,BAPTA-AM/25/B018,BAPTA 是由 Tsien 博士开发的钙选择性螯合剂

Product Description
BAPTA 是由 Tsien 博士开发的钙选择性螯合剂。 它的 logKCa=6.97 和 logKMg=1.77。 基本螯合单元类似于EGTA,但两个脂肪族氮原子被芳香族氮原子取代。 因此,BAPTA 在生理 pH 下不被质子化。 BAPTA 具有 pKa3=5.47 和 pKa4=6.36。 该性质表明去质子化步骤不包括在其钙络合步骤中,并且它具有比EGTA更高的络合率,因为它不受质子干扰的影响。 BAPTA-AM 是 BAPTA 的乙酰氧基甲酯衍生物,可以使用 AM 方法轻松加载到细胞中。 BAPTA-AM 可用于控制细胞内钙浓度。

Hydrolysis of AM ester

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