Pricing & Availability
- Clone
- 10/FR2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FR-β
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mice were IP injected with thioglycolate medium and peritoneal macrophages were collected after 4 days. The cells were then stained with FR-β (10/FR2) (filled histogram) or Rat IgG2a, κ isotype control (open histogram), followed by goat-anti-rat IgG PE.
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| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 153302 | 500 µg | $325.00 | ||||
Folate receptor beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product Details
Technical data sheet
Product Details
- Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Mouse Folate receptor β transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC – Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis
- Application References
(PubMed link indicates BioLegend citation)
-
- Nagai T, et al. 2009. Cancer Immunol Immunother. 1577-86.
- RRID
- AB_2687271 (BioLegend Cat. No. 153302)
Antigen Details
- Structure
- 30 kD, seven disulfide bonds
- Distribution
-
Placenta, monocytes, tissue resident macrophages
- Function
- Transport of folate into cells
- Ligand/Receptor
- Folic Acid
- Cell Type
- Macrophages, Monocytes
- Antigen References
-
1. Elwood PC, 1989, J Biol Chem, 264:14893.
2. Shen F, et al, 1994, Biochemistry, 8;33:1209.
3. Yi YS, 2016, Immune Netw,16:337. - Gene ID
- 14276 View all products for this Gene ID
- UniProt
- View information about Folate Receptor β on UniProt.org
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Other Formats
View All Folate Receptor β Reagents Request Custom Conjugation
| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse Folate Receptor β (FR-β) | 10/FR2 | FC |
| APC anti-mouse Folate Receptor β (FR-β) | 10/FR2 | FC |
| PE anti-mouse Folate Receptor β (FR-β) | 10/FR2 | FC |
| TotalSeq™-A0564 anti-mouse Folate Receptor β (FR-β) | 10/FR2 | PG |
| TotalSeq™-B0564 anti-mouse Folate Receptor β (FR-β) Antibody | 10/FR2 | PG |