Catalog #: 00194911
D-HBE-As – Diseased Human Bronchial/Tracheal Epithelial Cells from donors having Asthma
Product Overview
Lonza 的哮喘气道细胞包括肺成纤维细胞、支气管上皮细胞和支气管平滑肌细胞。支气管上皮细胞从肺分叉上方的气道上皮衬里分离出来。
哮喘是一种气道炎症性疾病，可导致患者出现喘息、气短、胸闷和咳嗽。严重程度因个体患者而异，对药物治疗的反应也是如此。嗜酸性粒细胞与支气管上皮细胞的粘附以及气道平滑肌和上皮下成纤维细胞的相互作用在哮喘病理学中起关键作用。在哮喘发作期间，细支气管平滑肌组织可以收缩和减少气道中的空气流动。炎症或粘液分泌过多可进一步减少气流量。
来自哮喘供体的冷冻保存的患病支气管上皮细胞的支原体、细菌、酵母和真菌检测呈阴性。并非所有供体和/或细胞批次都检测到 HIV-1、乙型肝炎和丙型肝炎。为购买的每个细胞批次提供分析证书。我们的目录号 00194911S 适用于气液界面研究，并保证促进气道上皮的完全分化，通过形成具有良好屏障功能（跨上皮阻力）、分泌表型（粘蛋白分泌）和纤毛发生的极化上皮表达。分化通常会在培养的第 22 天发生。
Benefits
- Test negative for mycoplasma, bacteria, yeast, and fungi
- HIV-1, Hepatitis B and Hepatitis C are not detected for all donors and/or cell lots
- A Certificate ofAnalysis is provided for each cell lot purchased
Applications
- Gene expression pathways
- Phenotypic changes to compounds
- Transfect diseased cells
- Co-culture with immune cells
- Airway remodeling studies
- Cellular interactions
Content & Storage
Content
1 x Cryopreserved ampule of D-HBE-As containing ≥500,000 cells
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