SPDP 是一种异双功能试剂，可用于桥接两种不同的蛋白质，例如酶和抗体。 SPDP 首先通过其氨基与蛋白质分子反应。 SPDP 将吡啶基二硫化物部分引入蛋白质，然后被 DTT 还原以形成硫醇基团。 然后这些硫醇基团与另一个蛋白质分子形成二硫键，从而产生异二聚体蛋白质。
Structural Formula
Structural Formula
Homo-bifunctional Reagents
| Product Name | Code | Length (Å) | Solvent |
| DSP | D629 | 8.5 | DMSO, DMF |
| SPDP | S291 | 4.1 | Acetonitrile |
1. P. Walden, Z. A. Nagy and J. Klein, Major Histocompatibility Complex-Restricted and Unrestricted Activation of Helper T Cell Lines by Liposome-bound Antigens, J. Mol. Cell. Immunol, 1986, 2, 191.2. R. D. Gordon, W. E. Fieles, D. L. Schotland, R. Hogue-Angeletti and R. L. Barchi, Topographical Localization of the C-terminal Region of the Voltagedependent Sodium Channel from Electrophorus Electricus Using Antibodies Raised Against a Synthetic Peptide, Proc. Natl. Acad. Sci. USA, 1987,84, 308.