Product Description of S-Nitrosothiols
亚硝基硫醇化合物在特定生理条件下释放 NO 并变成二硫化物。虽然大多数 S-亚硝基硫醇化合物不稳定，但 S-亚硝基谷胱甘肽却异常稳定。此外，S-亚硝基谷胱甘肽是水溶性的。尽管 S-亚硝基硫醇是一种良好的 NO 供体，没有硝酸盐耐受性，但有证据表明 S-亚硝基硫醇本身在鸟苷酸环化酶激活期间具有类似 NO 的活性。亚硝基硫醇的另一个重要反应是 NO 转移到其他硫醇化合物。由于它取决于硫醇的 pKa，因此该转移反应在生理 pH 水平下进行。这些亚硝基硫醇的弛豫效率已使用 Rataprta 环样品进行了比较：SNAP > S – N i t r o s o g l u t a t h i o n e = S – N i t r o s o – N-乙酰半胱氨酸>S-亚硝基辅酶 A>S-亚硝基-L-半胱氨酸。 Kowaluk 博士和其他人报告说，从 SNAP 中自发释放 NO 不能解释体外血管舒张。 NO 从亚硝基硫醇化合物中的自发释放可能不是血管舒张的关键因素。在细胞膜上产生的亚硝基硫醇代谢物可能是松弛的必要元素。
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