基本信息
| 产品名称 |
多球壳菌素 |
| 英文名称 |
Myriocin |
| 别名 |
Myriocin;ISP-1 |
| 英文别名 |
(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; ISP-I; Thermozymocidin |
| 应用 |
An inhibitor of sphingolipid biosynthesis with immunosuppressive properties. |
| 规格或纯度 |
98% |
| 运输条件 |
超低温冰袋运输 |
| 生化机理 |
Fungal metabolite with potent immunosuppressant activity. Inhibits serine palmitoyltransferase at picomolar concentrations blocking synthesis of ceramide, a precursor of sphingomyelin and glycosphingolipids. Disrupts substratum adhesion of melanoma cells. It has been sμggested that its immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction.Highly potent serine palmitoyltransferase inhibitor (K i = 0.28 nM). Shows 10 times the immunosuppressant potency of cyclosporine . Depletes cellular sphingolipids and induces apoptosis. Inhibits proliferation (IC 50 = 15 nM, CTLL-1 |
一般描述
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A. Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. It disrupts substratum adhesion of melanoma cells. It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) via apoptosis. Myriocin suppresses replication of the hepatitis C virus (HCV) in a murine model.
An inhibitor of sphingolipid biosynthesis with immunosuppressive properties.
安全信息
| 标识符号 |
 GHS06 |
| 信号词 |
Danger |
| 警示性声明 |
P301+P310 |
| 危害声明 |
H301 |
| 个人防护设备 |
dust mask type N95 (US),Eyeshields,Faceshields,Gloves |
| WGK |
3 |
| UN Number |
2811 |
相关属性
| CAS编号 |
35891-70-4 |
| 敏感性 |
对光线和湿度敏感 |
| 溶解性 |
Soluble in DMSO (heat briefly in boiling water bath) (25 mg/ml), dilute base (50 mM NaOH) (~5 mg/ml), and methanol (2 mg/ml). Insoluble in water. |
| 储存温度 |
-20°C储存 |
| RTECS |
JX3890000 |
| MDL号 |
MFCD01632772 |
| 密度 |
1.123 |
| 分子量 |
401.54 |
| 分子式 |
C21H39NO6 |
| 品牌 |
金畔生物 |
| 备注 |
如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID |
6438394 |
