标签：lonza CC-2925

Product Overview

Lonza 的人肾细胞包括从对每种细胞类型特异的各种正常人肾组织中分离出来的细胞。 人肾近端小管细胞从近端小管中分离出来，是药物转运蛋白研究的理想选择。

肾上皮细胞表现出极化形态，这对其功能至关重要。 它们重新吸收肾小球滤液中几乎所有的葡萄糖和氨基酸，同时允许其他没有营养价值的物质从尿液中排出。 渗透调节和排泄等生理过程可以在体外用 HRE 进行研究。 人肾上皮细胞也能够内化细菌，并且位于各种先天性、代谢和炎症性疾病的损伤部位附近。

Select References with Lonza’s Renal Cells and Media

• Diabetic Nephropathy is a chronic, progressive renal disease/diabetic kidney disease that develops in approximately one third of people with diabetes.  In a study, Lonza’s human proximal tubular epithelial cells were cultured in respective media (REGM^TM). The group investigated the role of KLK1 (kallikrein) in tubular pro-inflammatory responses in cultured human RPTEC and examined the role of PAR-4 (Protease-Activated Receptor 4) activation in KLK1-mediated signaling in the development of DN. Yiu WH, Wong DW, Chan LY, Leung JC, Chan KW, Lan HY, Lai KN, Tang SC. Tissue Kallikrein Mediates Pro-Inflammatory Pathways and Activation of Protease-Activated Receptor-4 in Proximal Tubular Epithelial Cells. PLoS ONE (2014); 9(2): e88894
• In another study, the role of micro RNA 1207-5P in the implication of Diabetic nephropathy was shown, where Lonza’s Mesangial cells and normal human renal proximal tubule epithelial cells were used. M. Lucrecia Alvarez , Mahdieh Khosroheidari, Elena Eddy, Jeff Kiefer. Role of MicroRNA 1207-5P and Its Host Gene, the Long Non-Coding RNA Pvt1, as Mediators of Extracellular Matrix Accumulation in the Kidney: Implications for Diabetic Nephropathy. PLoS ONE (2013); 8(10): e77468

RPTEC – 人肾近端小管上皮细胞 CC-2553

HRCE – 人肾皮质上皮细胞 CC-2554

HRE – 人肾上皮细胞 CC-2556