标签：HRCE – 人肾皮质上皮细胞

Product Overview

Lonza’s Human Renal Cells include cells isolated from various normal human kidney tissue specific to each cell type.  Human Renal Proximal Tubule Cells are isolated from the proximal tubule and are ideal for drug transporter studies. Human Renal Epithelial Cells (HRE) are comprised of cells from the cortex and glomerular region. Human Renal Cortical Cells (HRCE) are from proximal and distal tubules. Human Mesangial Cells (HMC) are isolated from the renal glomerulus and modified smooth muscle cells between capillaries.

Renal epithelial cells display a polarized morphology, which is essential for their function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine. Physiological processes like osmoregulation and excretion can be studied with renal epithelial cells in vitro.  Human renal epithelial cells are also capable of internalizing bacteria and are located near injury sites in a variety of congenital, metabolic and inflammatory diseases.

Lonza 的人肾细胞包括从对每种细胞类型特异的各种正常人肾组织中分离出来的细胞。人肾近端小管细胞从近端小管中分离出来，是药物转运蛋白研究的理想选择。人肾上皮细胞 (HRE) 由来自皮质和肾小球区域的细胞组成。人肾皮质细胞 (HRCE) 来自近端和远端小管。人系膜细胞 (HMC) 从肾小球和毛细血管之间的修饰平滑肌细胞中分离出来。

肾上皮细胞表现出极化形态，这对其功能至关重要。它们重新吸收肾小球滤液中几乎所有的葡萄糖和氨基酸，同时允许其他没有营养价值的物质从尿液中排出。可以在体外用肾上皮细胞研究渗透调节和排泄等生理过程。人肾上皮细胞也能够内化细菌，并且位于各种先天性、代谢和炎症性疾病的损伤部位附近。