标签：00194987

Product Overview

The human retinal pigment epithelium (H-RPE) consists of pigmented cells situated between the neuroretina and the choroids. The H-RPE is comprised of hexagonal cells organized into a monolayer that is densely packed with pigment granules. The H-RPE is of the neuroectodermal origin and is therefore considered to be part of the retina. H-RPE cells play a critical role in visual function and photoreceptor viability.

Lonza’s H-RPE (Human Retinal Pigment Epithelial) cells are cryopreserved, primary cells that are packaged at passage 2 and contain ≥500,000 cells per vial.  H-RPE are guaranteed through 5 population doublings and stain positive (≥90%) for pancytokeratin and Zo-1 and negative (≤10%) for fibroblast contamination and endothelial marker CD31 ( ≤1%). They also test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis (CoA) is provided for each cell lot purchased.

人视网膜色素上皮 (H-RPE) 由位于神经视网膜和脉络膜之间的色素细胞组成。 H-RPE 由六边形细胞组成，这些细胞组织成一个单层，其中密集地填充着颜料颗粒。 H-RPE 起源于神经外胚层，因此被认为是视网膜的一部分。 H-RPE 细胞在视觉功能和感光细胞活力方面发挥着关键作用。

Lonza 的 H-RPE（人视网膜色素上皮细胞）细胞是冷冻保存的原代细胞，在第 2 代时包装，每瓶含有 ≥500,000 个细胞。 H-RPE 通过 5 次群体倍增和泛细胞角蛋白和 Zo-1 染色阳性 (≥90%) 和成纤维细胞污染和内皮标志物 CD31 (≤1%) 染色阴性 (≤10%) 得到保证。 他们还检测出支原体、细菌、酵母和真菌呈阴性。 并非所有供体和/或细胞批次都检测到 HIV-1、乙型肝炎和丙型肝炎。 为购买的每个细胞批次提供分析证书 (CoA)。