Product Overview
Stellate cells are a resident cell type of the liver primarily functioning to store retinoids. In response to liver damage, stellate cells rapidly lose the stored retinoids and differentiate into a proliferating fibroblast-like cell that begins depositing collagen matrix. This activity causes buildup of collagen in the liver eventually leading to cirrhosis.
Stellate cells can be isolated from liver tissue, enriched, and placed into cell culture. When placed into culture, stellate cells begin to immediately differentiate into the activated state.
Human Cryopreserved Stellate Cells, 100K cells/vial, are stellate cells enriched from human liver isolations and grown to >80% confluency and then cryopreserved.
Human Stellate Growth Medium (Catalog MCST250) is available to support optimal culture health and growth characteristics of stellate cells.
星状细胞是肝脏的一种常驻细胞类型，主要功能是储存类维生素A。 作为对肝损伤的反应，星状细胞迅速失去储存的类维生素A并分化成增殖的成纤维细胞样细胞，开始沉积胶原蛋白基质。 这种活动会导致肝脏中胶原蛋白的堆积，最终导致肝硬化。
星状细胞可以从肝组织中分离、富集并放入细胞培养物中。 当放入培养物中时，星状细胞开始立即分化成活化状态。
人冷冻保存的星状细胞，100K 细胞/瓶，是从人肝分离物中富集的星状细胞，并生长到 >80% 的汇合度，然后冷冻保存。
人星状生长培养基（目录 MCST250）可用于支持星状细胞的最佳培养健康和生长特性。
Characterization performed:
- Post-thaw plating to observe characteristic stellate morphology.
- Flow cytometry using antibodies for Vinculin, Vimentin, and α-SMA
Benefits
- Low Passage
- High activation potential
Applications
- ADMETox
- Liver Disease
- NASH
Content & Storage
Content
Cryo Vial
100,000 cells/ vial
